https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Monitoring patient response to pembrolizumab with peripheral blood exhaustion marker profiles https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44986 Wed 26 Oct 2022 15:06:56 AEDT ]]> Classification of schizophrenia using differential gene expression in peripheral blood lymphocytes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2967 Wed 24 Jul 2013 22:50:59 AEST ]]> Immune checkpoint blockade in solid organ tumours: choice, dose and predictors of response https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39903 Wed 22 Mar 2023 10:31:41 AEDT ]]> Epigenetic mechanisms and therapeutic targets in chemoresistant high-grade serous ovarian cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48589 Wed 22 Mar 2023 08:32:47 AEDT ]]> Low tumour-infiltrating lymphocyte density in primary and recurrent glioblastoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48900 Wed 19 Apr 2023 16:40:13 AEST ]]> Confirmation of childhood acute lymphoblastic leukemia variants, ARID5B and IKZF1, and interaction with parental environmental exposures https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16807 -9), and IKZF1 rs1110701 (OR 1.69, CI 1.42–2.02, p = 7.26 x 10-9). There was evidence of gene-environment interaction for risk genotype at IKZF1, whereby an apparently stronger genetic effect was observed if the mother took folic acid or if the father did not smoke prior to pregnancy (respective interaction P-values: 0.04, 0.05). There were no interactions of risk genotypes with age or sex (P-values >0.2). Our results evidence that interaction of genetic variants and environmental exposures may further alter risk of childhood ALL however, investigation in a larger population is required. If interaction of folic acid supplementation and IKZF1 variants holds, it may be useful to quantify folate levels prior to initiating use of folic acid supplements.]]> Wed 11 Apr 2018 16:52:33 AEST ]]> Regulators of global genome repair do not respond to DNA damaging therapy but correlate with survival in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14356 Wed 11 Apr 2018 15:41:30 AEST ]]> STaRRRT: a table of short tandem repeats in regulatory regions of the human genome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14811 Wed 11 Apr 2018 14:25:00 AEST ]]> Gene expression profiling of Xeroderma pigmentosum https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1111 Wed 11 Apr 2018 13:29:26 AEST ]]> Understanding xeroderma pigmentosum complementation groups using gene expression profiling after UV-light exposure https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20527 Wed 11 Apr 2018 13:11:00 AEST ]]> The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12520 Wed 11 Apr 2018 12:41:53 AEST ]]> P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13895 Wed 11 Apr 2018 11:47:28 AEST ]]> Altered gene expression in the superior temporal gyrus in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4362 Wed 11 Apr 2018 11:36:43 AEST ]]> Whole genome amplification and its impact on CGH array profiles https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4380 Wed 11 Apr 2018 10:34:48 AEST ]]> BCL-2 family isoforms in apoptosis and cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36748 Wed 10 Nov 2021 15:04:41 AEDT ]]> Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32798 Wed 09 Mar 2022 16:01:33 AEDT ]]> Nucleotide excision repair deficiency in melanoma in response to UVA https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24616 40 % of lesions remained in melanoma cell lines at 48 h. This was coupled with a delayed and reduced induction of GGR component XPC in melanoma cells, independent of p53. Conclusion: These findings support that NER activity is reduced in melanoma cells due to deficient GGR. Further investigation into the role of NER in UVA-induced melanomagenesis is warranted and may have implications for melanoma treatment.]]> Wed 09 Feb 2022 15:53:41 AEDT ]]> Vasculogenic Mimicry Occurs at Low Levels in Primary and Recurrent Glioblastoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54632 Wed 06 Mar 2024 10:59:47 AEDT ]]> DNA damage repair in glioblastoma: current perspectives on its role in tumour progression, treatment resistance and PIKKing potential therapeutic targets https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48767 Wed 05 Apr 2023 13:55:36 AEST ]]> Repair of UVB-induced DNA damage is reduced in melanoma due to low XPC and global genome repair https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27853 T transitions. These mutations are found throughout the melanoma genome, particularly in non-transcribed regions. The global genome repair (GGR) branch of nucleotide excision repair (NER) is responsible for repairing UV-induced DNA damage across non-transcribed and silent regions of the genome. This study aimed to examine the relationship between UVB and GGR in melanoma. DNA repair capacity and relative expression of NER in melanocytes and melanoma cell lines before and after treatment with UVB was quantified. Transcript expression from 196 melanomas was compared to clinical parameters including solar elastosis and whole transcriptome data collected. Melanoma cell lines showed significantly reduced DNA repair when compared to melanocytes, most significantly in the S phase of the cell cycle. Expression of GGR components XPC, DDB1 and DDB2 was significantly lower in melanoma after UVB. In the melanoma tumours, XPC expression correlated with age of diagnosis and low XPC conferred significantly poorer survival. The same trend was seen in the TCGA melanoma dataset. Reduced GGR in melanoma may contribute to the UV mutation spectrum of the melanoma genome and adds further to the growing evidence of the link between UV, NER and melanoma.]]> Wed 02 Mar 2022 14:27:55 AEDT ]]> Targeting Homologous Recombination Deficiency in Ovarian Cancer with PARP Inhibitors: Synthetic Lethal Strategies That Impact Overall Survival https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52889 Tue 31 Oct 2023 15:47:10 AEDT ]]> Bilateral dysgerminoma associated with gonadoblastoma and sex-cord stromal tumour with annular tubules in a 28-year-old fertile woman with normal karyotype https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17482 Tue 16 Jun 2015 15:34:15 AEST ]]> Sequential azacitidine and carboplatin induces immune activation in platinum-resistant high-grade serous ovarian cancer cell lines and primes for checkpoint inhibitor immunotherapy https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48290 Tue 14 Mar 2023 11:54:53 AEDT ]]> A polymorphic repeat in the IGF1 promoter influences the risk of endometrial cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26531 Thu 28 Oct 2021 12:37:29 AEDT ]]> A novel polymorphic repeat in the upstream regulatory region of the estrogen-induced gene EIG121 is not associated with the risk of developing breast or endometrial cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30240 EIG121) has been associated with breast and endometrial cancers, but its mechanism of action remains unknown. In a genome-wide search for tandem repeats, we found that EIG121 contains a short tandem repeat (STR) in its upstream regulatory region which has the potential to alter gene expression. The presence of this STR has not previously been analysed in relation to breast or endometrial cancer risk. Results: In this study, the lengths of this STR were determined by PCR, fragment analysis and sequencing using DNA from 223 breast cancer patients, 204 endometrial cancer patients and 220 healthy controls to determine if they were associated with the risk of developing breast or endometrial cancer. We found this repeat to be highly variable with the number of copies of the AG motif ranging from 27 to 72 and having a bimodal distribution. No statistically significant association was identified between the length of this STR and the risk of developing breast or endometrial cancer or age at diagnosis. Conclusions: The STR in the upstream regulatory region of EIG121 is highly polymorphic, but is not associated with the risk of developing breast or endometrial cancer in the cohorts analysed here. While this polymorphic STR in the regulatory region of EIG121 appears to have no impact on the risk of developing breast or endometrial cancer, its association with disease recurrence or overall survival remains to be determined.]]> Thu 28 Oct 2021 12:35:27 AEDT ]]> Overall survival in metastatic melanoma correlates with pembrolizumab exposure and T cell exhaustion markers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46496 Thu 24 Nov 2022 12:14:09 AEDT ]]> Contraceptive use and contraceptive counselling interventions for women of reproductive age with cancer: a systematic review and meta-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51176 Thu 24 Aug 2023 14:31:05 AEST ]]> ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54816 Thu 14 Mar 2024 14:38:44 AEDT ]]> Repurposing azacitidine and carboplatin to prime immune checkpoint blockade-resistant melanoma for anti-PD-L1 re-challenge https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49310 Thu 11 May 2023 14:39:28 AEST ]]> Metastatic melanoma treatment: combining old and new therapies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29594 Thu 03 Feb 2022 12:21:03 AEDT ]]> Melanoma: An immunotherapy journey from bench to bedside https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48125 Thu 02 Mar 2023 15:06:34 AEDT ]]> Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1288 Sat 24 Mar 2018 08:32:45 AEDT ]]> Altered gene expression in the amygdala in schizophrenia: up-regulation of genes located in the cytomatrix active zone https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1231 Sat 24 Mar 2018 08:28:34 AEDT ]]> BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12510 Sat 24 Mar 2018 08:18:42 AEDT ]]> Nucleotide excision repair gene expression after cisplatin treatment in melanoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11525 Sat 24 Mar 2018 08:10:22 AEDT ]]> IL-27/IFN-γ induce MyD88-dependent steroid-resistant airway hyperresponsiveness by inhibiting glucocorticoid signaling in macrophages https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11518 Sat 24 Mar 2018 08:10:22 AEDT ]]> Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20955 Sat 24 Mar 2018 08:06:07 AEDT ]]> Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19125 C) were found. In addition, five variants predicted to be protein-affecting were also identified. Our study shows that the prevalence of PALB2 germline mutations in individuals with TNBC is ~1%, similar to the prevalence of PALB2 germline mutation of 1% in familial non-BRCA1/2 breast cancer cohorts.]]> Sat 24 Mar 2018 07:55:57 AEDT ]]> Common genetic variants in the plasminogen activation pathway are not associated with multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19188 Sat 24 Mar 2018 07:55:01 AEDT ]]> Altered expression of the plasminogen activation pathway in peripheral blood mononuclear cells in multiple sclerosis: possible pathomechanism of matrix metalloproteinase activation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19980 Sat 24 Mar 2018 07:50:58 AEDT ]]> Dysregulation of miRNA 181b in the temporal cortex in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5407 Sat 24 Mar 2018 07:48:18 AEDT ]]> Potential association of vitamin D receptor polymorphism Taq1 with multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22288 Sat 24 Mar 2018 07:17:30 AEDT ]]> MC1R CpG island regulates MC1R expression and is methylated in a subset of melanoma tumours https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48085 Fri 24 Feb 2023 14:56:04 AEDT ]]> Transcriptomic Profiling of DNA Damage Response in Patient-Derived Glioblastoma Cells before and after Radiation and Temozolomide Treatment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51740 Fri 15 Sep 2023 18:14:17 AEST ]]> Characteristics of vasculogenic mimicry and tumour to endothelial transdifferentiation in human glioblastoma: a systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51543 Fri 08 Sep 2023 14:59:23 AEST ]]> Biomarkers of platinum resistance in ovarian cancer: What can we use to improve treatment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44103 Fri 07 Oct 2022 13:51:30 AEDT ]]>